Application

Research Sub CategoryTumor Markers

Research CategoryApoptosis & Cancer

Anti-SND1, clone 2D7 Antibody detects level of SND1 & has been published & validated for use in SND1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Staphylococcal nuclease domain-containing protein 1, also known as 100 kDa coactivator or EBNA2 coactivator p100 or Tudor domain-containing protein 11 or p100 co-activator, and encoded by the gene name SND1 or TDRD11, plays an important role in PIM1 regulation of MYB acitivity and acts as a transcriptional activatior of EBNA-2. SND1 also interacts with EAV, NSP1,GTF2E1 and GTF2E2, and forms a ternary complex with STAT6 and POLR2A. SND1 ic localized to the cytoplasm and in IL-4 stimulated cells SND1 co-localizes with STAT6 in the nucleus. SND1 plays an important role in the assembly of STAT6 transcriptome and stimulates IL-4-dependent transcription by mediating interaction between STAT6 and CBP.

Immunogen

Purified recombinant fragment of human SND1 expressed in E. Coli

Physical form

Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.

Unpurified

Quality

Evaluated by Western Blotting in HeLa, Jurkat, HepG2, and SMMC-7721 cell lysates.

Western Blotting Analysis: A 1:500-1:2,000 dilution of this antibody detected SND1 in HeLa, Jurkat, HepG2, and SMMC-7721 cell lysates.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Target description

~102 kDa observed. Uncharacterized bands may be observed in some lysate(s).